Caduet consists of Amlodipine besylate and atorvastatin calcium. Caduet has a double mechanism of action; action of amlodipin as dihydropyridinic antagonist of calcium and for suppression of atorvastatin HMG-CoA reductase. It is taken for prevention of cardiovascular events at patients with hypertension, with three concurrent factors of cardiovascular risk, with cholesterol level from normal to moderately raised, without clinical manifestations of ischemic heart disease and also when according to the existing recommendations about treatment the combined use of amlodipin and low dose of atorvastatin is deemed appropriate.
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- Product Description
- Safety Information
- Side Effects
Caduet is a combination drug prescribed as an antihypertensive, antianginal and lipid-lowering agent for the treatment of combined cardiovascular diseases. Caduet is prescribed to children aged 6 and older, adults and elderly people to reduce the risk of cardiovascular complications in the availability of such risk factors as coronary heart disease, type 2 diabetes mellitus.
Due to the antihypertensive effect, Caduet helps to reduce blood pressure and effectively treats hypertension, reducing the risk of myocardial infarction and stroke. Moreover, Caduet can be prescribed for the symptomatic treatment of chronic stable angina and vasospastic angina and for the reduction of angina risk in patients with coronary heart disease.
If non-drug methods of dyslipidemia treatment and lipid-lowering diets are ineffective, hypertensive patients can be prescribed with Caduet combination drug. The initial dose of antihypertensive drug is selected individually taking into account the patient’s tolerability and efficacy of treatment. This drug is taken orally, one tablet once a day, regardless of meals.
During Caduet use, the patient needs to follow the prescribed dosage regimen and to try not to skip the therapeutic dose. If the patient misses a dose of the antihypertensive drug, he or she should take it as soon as he remembers. If more than 12 hours have passed, the missed dose of Caduet should be skipped. The next therapeutic dose is to be taken on the regular schedule without doubling.
Before to start using Caduet tablets, the patient can be advised to start a hypoglycemic diet and to limit the consumption of saturated fats. During Caduet use, the patient needs to limit alcohol use, quit smoking and avoid smoky places.
Caduet is not recommended for pregnant women. Women of childbearing age need to choose effective methods of contraception, since Caduet may cause harm to the fetus. Caduet use is contraindicated if the patient has a severe form of liver disease.
Cholesterol-lowering medication must be stored away from light and moisture, out of the reach of children, at temperature not above 25°C. Do not use expired Caduet tablets and throw them away in time.
During Caduet trials, it was found that the drug might affect skeletal muscles and cause myopathy and myositis. At the first signs of muscle disorders, the use of Caduet tablets should be stopped.
The risk of myocardial infarction can be increased and severe angina may occur in patients with obstructive coronary artery disease using high doses of Caduet. Caduet is used with caution in patients with severe aortic stenosis because the drug can cause symptomatic hypotension.
Concomitant use of Caduet with contraceptives containing norethindrone and ethinyl estradiol increases the concentration of oral contraceptives in the blood plasma. Caduet may affect the antihypertensive and lipid-lowering effects of other drugs, such as gemfibrozil, nicotinic acid, spironolactone, digoxin, fenofibrate, bezafibrate, and beta-blockers.
This Caduet review is for information only; therefore, it should not be used as a substitute for diagnostic tests and consultation with experts in cardiovascular diseases. The online pharmacy does not accept any medical or legal responsibility for the consequences of any actions based on the use or inability to use information about Caduet, management of hyperlipidemia, treatment of hypertension and prevention of cardiovascular diseases.
During Caduet drug therapy, a variety of unwanted effects may arise, among which the most common is peripheral edema. Fluid retention occurs in about 10% of patients using Caduet. Less frequently, Caduet causes headache (5%).
After using Caduet tablets, approximately 2% of patients experience dizziness, asthenia, abdominal pain and vasodilatation. Sometimes, Caduet causes palpitations, flushing and somnolence. These unwanted effects occur in men more frequently than in women.
The most common reasons for Caduet withdrawal are severe: diarrhea, peripheral edema or myalgia. If these unwanted effects are mild to moderate, it is not required to stop antihypertensive or antianginal therapy.